CHAPTER 3532

 

 

 

SOMATIZATION

Adriana Feder, M.D.

 

The term "somatization" describes a tendency to experience and communicate psychological distress in the form of physical symptoms. Somatic symptoms often occur in reaction to stressful situations and are not considered abnormal if they occur sporadically. Some individuals, however, experience continuing somatic symptoms, attribute them to physical illness in spite of the absence of medical findings, and seek medical care for them. Somatization may also coexist with a medical disease, but when it does the symptoms are out of proportion to the demonstrable medical findings.

Persistent somatization affects a significant percentage of patients in the primary care setting, and is associated with considerable distress and disability. In a recent study of 1,456 primary care patients, 22 percent were found to have several persistent, impairing and medically unexplained symptoms that led to physician visits. In a sample of 271 patients in the Associates in Internal Medicine (AIM) practice, primary care physicians identified 24 percent of patients as having a history of multiple medically unexplained symptoms. Somatization leads to over-utilization of medical care and often to increased hospitalization rates., Unnecessary medical tests and procedures place patients at risk for iatrogenic complications. At times, a medical disease may be misdiagnosed as somatization. In addition, the care of patients with somatization is often frustrating for both patient and physician.

Somatizing patients do not represent a homogeneous group. Not all somatizing patients are motivated by an unconscious wish to adopt the sick role, as is observed in patients with factitious disorder and in some patients with somatization disorder. Patients also vary in their degree of conviction that their symptoms are caused by a physical disease. Patients with medically unexplained symptoms in the primary care setting may be grouped into three broad categories: patients who present with multiple unexplained somatic symptoms, patients who exhibit predominantly illness worry or hypochondriacal beliefs, and patients in whom somatization is actually a manifestation of major depression or an anxiety disorder. Unexplained somatic symptoms are more frequent in women than men. However, men are more often "true somatizers," meaning that they are more likely to deny a psychological component to their physical symptoms when asked about them. Illness worry affects both sexes equally. While some studies have found that individuals from certain ethnic groups, such as Hispanics, have a higher tendency to exhibit medically unexplained symptoms when depressed, recent research shows that somatization exists across cultures.,

Patients with multiple unexplained somatic symptoms have significantly higher rates of depressive and anxiety disorders. As above, there are patients for whom somatization may beis primarily a manifestation of a depressive or anxiety disorder. Cross-cultural studies have shown that individuals from some ethnic groups, such as Hispanics, have a higher tendency to exhibit medically unexplained symptoms when depressed. Other patients suffer from an independent chronic somatoform disorder but are at risk for developing a superimposed depressive or anxiety disorder. The higher the number of medically unexplained symptoms, the higher the likelihood of having a depressive or anxiety diagnosis. A primary care study found that as the number of physical symptoms reported by a patient increased from 0 to 9 or more, the likelihood of a mood disorder diagnosis increased from two percent to 60 percent, and the likelihood of an anxiety disorder diagnosis increased from one percent to 48 percent. In the above-mentioned study conducted at AIM, patients with a history of multiple medically unexplained symptoms had over twice the rate of any current psychiatric disorder when compared to patients without such history. As a group, they reported significantly greater overall emotional impairment and poorer social adjustment.

It is thus important to screen all somatizing patients for depressive and anxiety disorders. Patients in the primary care setting tend to report physical symptoms more readily than they report psychological distress. This may in part explain physician underdetection of depressive and anxiety disorders. Although patients with somatized depression or anxiety may not spontaneously bring up psychosocial issues, most are willing to discuss emotional distress and related psychosocial stressors if asked appropriately. Patients with somatoform disorders vary in their degree of openness to considering a psychological component to their symptoms.

Although the optimal approach to somatizing patients is unknown, some useful principles have been described. The physician evaluating a patient with difficult-to-explain somatic symptoms must establish an alliance with the patient and understand that the symptoms are not intentionally produced. The initial evaluation consists of excluding significant medical disease while looking for evidence of psychological distress. It is important to assess whether the symptoms are acute or chronic, and whether they seem precipitated or maintained by identifiable psychosocial stressors. The physician must also determine if the patient suffers from a psychiatric disorder such as depression or anxiety, even if the patient denies any contributory psychosocial issues. Following the steps in the Patient Interview and Diagnosis section below will assist the physician to evaluate the patient and devise an appropriate treatment plan.

Etiology

Somatization encompasses a number of heterogeneous conditions with a wide range of proposed etiological factors, more than one of which may be involved in a particular patientís presentation. In some cases, somatization may be a result of autonomic arousal under the influence of stress or anxiety Ė for example, stress-induced increased esophageal motility can cause chest pain, and respiratory alkalosis due to hyperventilation can lead to paresthesias. In fact, somatization is commonly precipitated by stressful life events, such as bereavement, physical illness, and breakup of a relationship. Somatization may also be a manifestation of depression or of an anxiety disorder. Sociocultural factors may additionally contribute, as indicated by the finding that unexplained somatic symptoms are more prevalent in some cultural groups, including Hispanics and Asians. In societies where mental illness is stigmatized, somatization may provide a socially acceptable way of communicating distress. A more extreme but infrequent form of somatization, somatization disorder, appears to have a genetic component; this is supported by adoption studies showing a higher prevalence of antisocial behavior in the biological parents of adopted-away women with somatization disorder.

Other studies have shown that hypochondriasis and somatization are associated with a history of childhood trauma Ė such as sexual or physical abuse Ė and with traumatic experiences in adulthood., Exposure to parental chronic illness or illness behavior during childhood also increases the risk of somatization in adulthood, suggesting that learned behavior during development may play a role. Later in life, illness behavior may be maintained by external reinforcers Ė families, physicians, or disability payments. In patients with conversion symptoms, psychoanalytic theory has proposed that the symptoms may "solve" an unconscious conflict (primary gain); for example, a person may experience arm weakness after angrily wishing to punch a friend but fearing the consequences of this action. Secondary gain refers to the unconscious benefits that patients derive from the sick role. This term is often misused to indicate the conscious pursuit of external incentives, such as purposely avoiding work or evading criminal prosecution. It is often difficult to ascertain whether a patientís motivations are conscious or not. In the absence of external incentives, living life as a sick person can hardly be an appealing conscious choice for patients with chronic somatization.

Patient Interview and Diagnosis

A basic evaluation can often be completed during the first patient visit. Further assessment generally continues during subsequent visits, especially in more complex cases. Patient evaluation should include a complete history, physical examination, and appropriate laboratory tests in order to exclude underlying physical disease. Patients with illnesses that tend to present initially with nonspecific or vague symptoms, such as multiple sclerosis or lupus erythematosus, may be mistakenly identified as somatizers., While proceeding with the medical work-up, the physician should simultaneously look for evidence of psychological distress. and remain aware that somatic symptoms "are not simply indices of disease or disorder but part of a language of distress with interpersonal and wider social meanings" that the physician "must learn to decode." The following steps should guide the evaluation of a patient with difficult-to-explain somatic symptoms:

Psychiatric Disorders

Somatization and Adjustment Disorder:

Although medically unexplained symptoms are not explicitly mentioned in the DSM-IV definition of Adjustment Disorder, acute somatic symptoms are a common response to stress. Adjustment disorder is defined as clinically significant emotional or behavioral symptoms in response to an identifiable psychosocial stressor or stressors., Patients with this condition may exhibit depressed mood, anxiety or both. By definition, the symptoms of an adjustment disorder do not last more than six months after the stressor has terminated and do not meet severity criteria for major depression or anxiety disorder.

Somatization and Mood Disorders:

Mood disorders commonly associated with unexplained somatic symptoms include Major Depression and Dysthymic Disorder. Patients with current or past depression report higher numbers of somatic symptoms than patients without a mood disorder. Pain is a particularly common symptom in depression, e.g. back pain, headaches and muscle soreness., Over half of depressed patients report pain symptoms, and women may be more likely than men to exhibit pain as a symptom of depression., Depression may decrease the threshold for pain from any etiology. Studies have also found that depression is associated with illness worry and a negative view of oneís health. This implies that some patients who appear to suffer from hypochondriasis may actually have major depression. In depressed patients, both illness worry and reporting of physical symptoms diminish with treatment of depression. Chapter 30 reviews the assessment of patients for major depression or dysthymic disorder.

Somatization and Anxiety Disorders:

Most patients with Panic Disorder report primarily somatic symptoms. This makes them vulnerable to underdiagnosis. Often, after a negative medical work-up, patients are told that they do not have evidence of a medical condition, but panic disorder remains undiagnosed and untreated. Panic attacks are episodic and may include a variety of symptoms such as chest pain, tachycardia, nausea, dizziness, shortness of breath, numbness, or tingling, among others. In one study, 30 to 50 percent of ambulatory patients with chest pain and negative work-ups for coronary artery disease were found to have panic disorder. Some patients with irritable bowel syndrome are also found to have panic disorder. Symptoms often resolve with treatment of panic disorder. Treatment of panic disorder also improves hypochondriacal worry. Other anxiety disorders that may present with unexplained somatic symptoms in the primary care setting include Generalized Anxiety Disorder and Posttraumatic Stress Disorder. See Anxiety chapter for a description of the individual anxiety disorders.

Somatoform Disorders:

The Somatoform Disorders are a group of heterogeneous disorders characterized by physical symptoms that suggest a general medical condition, but are not fully explained by a general medical condition, the effects of a substance, or another mental disorder. The symptoms are not intentionally produced and cause significant distress or impairment in functioning. A somatoform disorder is diagnosed only if the medically unexplained symptoms are not primarily the result of another psychiatric disorder, such as major depression or panic disorder. However, major depression or panic disorder may coexist with one of the somatoform disorders. The somatoform disorders include Somatization Disorder, Undifferentiated Somatoform Disorder, Hypochondriasis, Pain Disorder, Body Dysmorphic Disorder, Conversion Disorder, and Somatoform Disorder Not Otherwise Specified. These disorders are grouped together based on clinical utility rather than a shared etiology or pathophysiology.

TABLE I: Psychiatric disorders that may be associated with somatization

Adjustment Disorder

Mood Disorders

Major Depression

Dysthymic Disorder

Other

Anxiety Disorders

Panic Disorder

Generalized Anxiety Disorder

Post Traumatic Stress Disorder

Other

Somatoform Disorders

Somatization Disorder

Undifferentiated Somatoform Disorder

Hypochondriasis

Pain Disorder

Conversion Disorder

Body Dysmorphic Disorder

Somatoform Disorder Not Otherwise Specified

Other Psychiatric Disorders

Alcohol or Substance Abuse

Psychotic Disorders

Personality Disorders

Factitious Disorder

 

Somatization Disorder:

Somatization Disorder is a chronic condition with a waxing and waning course. Patients have multiple medically unexplained physical complaints. Although by definition these physical complaints must begin before age 30, symptoms usually begin in the teens or early twenties. The symptoms lead patients to seek treatment or result in significant impairment in social or occupational functioning. If the patient has a coexisting medical condition, the physical complaints or level of impairment are in excess of what would be expected from the history, physical examination, or laboratory tests. In order to meet DSM-IV criteria for somatization disorder, a patient must have a history of at least four pain symptoms, two gastrointestinal symptoms other than pain, one sexual symptom, and one pseudoneurological symptom (e.g. weakness or double vision) over time. Patients see themselves as "sickly" and often have multiple psychosocial problems.

Most primary care patients with unexplained somatic symptoms do not meet criteria for somatization disorder., Its prevalence rate in primary care is two to five percent. It is more common in women. Up to 75 percent of patients with somatization disorder have other co-morbid psychiatric disorders, most commonly major depression, panic disorder and dysthymic disorder. , Some have a co-morbid personality disorder or a history of substance abuse. Patients with somatization disorder may be particularly frustrating to work with. It is important to remain aware of countertransference feelings and to remember that the patientsí symptoms are not intentionally produced.

Undifferentiated Somatoform Disorder:

The essential feature of this disorder is one or more unexplained physical complaints that persist for six months or longer and cause significant distress or impairment. Many primary care patients with multiple unexplained medical symptoms who do not meet the strict diagnostic criteria for somatization disorder may fall in this category. Patients initially diagnosed with undifferentiated somatoform disorder are often eventually diagnosed with a medical condition or another mental disorder.

 

Hypochondriasis:

Patients with Hypochondriasis experience fears of having, or believe that they have, a serious disease based on their misinterpretation of bodily symptoms. This preoccupation persists despite appropriate medical evaluation and reassurance, and causes significant distress or impairment in function. This disorder is diagnosed when fear of illness, rather than somatic symptoms, is more prominent. A classic example is that of a patient who remains convinced that he has cancer in spite of a negative work-up and repeated reassurances to the contrary. In order to diagnose hypochondriasis, this fear or belief must persist for at least six months and cannot be due primarily to another psychiatric disorder. "Doctor-shopping" and high medical utilization are common, as are frustration and anger on the part of both patient and physician.

Hypochondriasis affects approximately three percent of primary care patients and is equally prevalent in men and women. As discussed above, patients with depressive or anxiety disorders also commonly experience increased illness worry, so it is important to determine whether a patient has major depression, an anxiety disorder, or primary hypochondriasis. On the other hand, patients who have hypochondriasis are at risk for co-morbid major depression, so both disorders may be present in some patients.

Pain Disorder:

In this disorder, pain is the predominant focus of the clinical presentation and is of sufficient severity to warrant clinical attention. In order to make this diagnosis, psychological factors must be judged to have an important role in the onset, severity, exacerbation, or maintenance of the pain. The pain causes significant distress or impairment in function, and is not intentionally produced or feigned. If another psychiatric disorder better accounts for the pain, then that disorder is diagnosed instead. Patients with pain disorder are at risk for iatrogenic complications such as dependence on narcotic analgesics or unnecessary surgical interventions. In patients with pain disorder, both a medical condition and psychological factors may coexist. Patients with chronic pain often have co-morbid major depression.

Conversion Disorder:

The essential feature of Conversion Disorder is the presence of motor or sensory symptoms or deficits that suggest a neurological or other medical condition (e.g. impaired balance, weakness, or double vision) but cannot be fully explained by a medical condition, the effects of a substance, or a culturally-sanctioned experience. This diagnosis is made when psychological factors, such as conflicts or stressors, are judged to be temporally associated with the onset of the symptoms or deficits. The symptoms cause significant distress or impairment. Careful consideration of possible medical diagnoses is advised, given the frequency of cases misdiagnosed as conversion disorder.

Body Dysmorphic Disorder:

Patients with Body Dysmorphic Disorder are preoccupied with an imagined defect in appearance. If a slight physical anomaly is actually present, the patientís concern is markedly excessive. This preoccupation causes significant distress or impairment in function. Patients with this disorder more commonly present to surgery clinics. Up to 50 percent of patients may have co-morbid major depression. In some patients, preoccupation with an imagined defect in appearance may represent a delusional belief.

Somatoform Disorder Not Otherwise Specified:

This diagnosis applies to patients with medically unexplained symptoms that do not meet criteria for any specific somatoform disorder, e.g. hypochondriacal or somatic symptoms of less than six monthsí duration.

Factitious disorder:

Factitious Disorder is not considered a somatoform disorder but shares some characteristics with the somatoform disorders. It is characterized by physical or psychological symptoms that are intentionally produced or feigned. The motivation for this behavior is to assume the sick role. External incentives Ė as in malingeringĖ are absent. The extreme form of factitious disorder is often called Munchhausen syndrome.

Malingering:

Malingering is not a psychiatric disorder. Its essential feature is the intentional production of false or exaggerated symptoms, motivated by external incentives such as avoiding prosecution or obtaining financial compensation. In some cases, it may be adaptive, e.g. a prisoner of war who feigns illness.

 

Treatment

Acute Somatic Symptoms:

If the patientís symptoms are part of a normal reaction to stress or an adjustment disorder, the physician should reassure the patient that there is no disease that requires medical treatment, and explain that physical symptoms are a common reaction to stressful events. Listening to the patientís concerns and supporting the patientís natural coping skills is often sufficient. Patients with an adjustment disorder by definition exhibit a higher level of distress. A reasonable first strategy is to observe the patient over time, provide counseling in the office, and encourage the patient to seek support from family and friends. Some patients may benefit from a psychotherapy referral to help them cope with acute stressors. The physician should also keep in mind that in some cases acute somatic symptoms represent the onset of major depression or panic disorder. In these cases, treatment should be instituted early.

Chronic Somatic Symptoms:

Whether the physician is initiating medical care for a new patient with a history of somatization or continuing care for a well-known patient, the following management techniques may be helpful in working with patients who exhibit chronic somatization:,,

Examples of Treatments for Specific Disorders:

More specialized treatment is best instituted by a psychiatrist or in consultation with a psychiatrist:

Summary

Somatization is a general term that describes the presence of medically unexplained symptoms and implies a psychological component to the symptoms. Persistent somatization is associated with increased rates of disability and health care utilization. Patients should be assessed for the presence of a psychiatric disorder, especially a depressive or an anxiety disorder. Therapeutic interventions consist of treating depressive and anxiety disorders when present and instituting a general approach to the patient aimed at maintaining the therapeutic alliance, improving the patientís functional status, and minimizing unnecessary medical tests. A referral for psychiatric consultation or treatment should be considered.