Hematology
Overview
The discipline of hematology relates to the care of patients with disorders of the blood, bone
marrow, and lymphatic systems, including anemias, hematologic malignancies, and other clonal
processes, and congenital and acquired disorders of hemostasis, coagulation, and thrombosis.
The general internist should be competent in 1) the detection of abnormal physical, laboratory,
and radiologic findings relating to the lymphohematopoietic system; 2) the assessment of the
need for bone marrow aspirate and biopsy and lymph node biopsy; 3) the initial diagnostic
evaluation and management of the hemostatic and clotting system; 4) the assessment of the
indications and procedure for transfusion of blood and its separate components; 5) the
management of therapeutic and prophylactic anticoagulation; 6) the diagnosis and management
of common anemias; 7) the pharmacology and use of common chemotherapies; and 8) the
management of neutropenia/immunosuppression.
The range of competencies expected for a general internist will vary depending on the
availability of a hematologist in the primary care setting. For example, in some communities a
general internist may be responsible for bone marrow examination and administration of
chemotherapy for certain disorders in conjunction with consultative assistance from appropriate
hematologist and pathologist colleagues.
(N.B. Leukemias and lymphomas are found in the Oncology section.)
Common Clinical Presentations
·
Abnormalities of peripheral smear·
Bleeding, bruising, or petechiae·
Family history of anemia or bleeding disorder·
Lymphadenopathy·
Pallor or fatigue·
Recurrent infections or fever/neutropenia·
Splenomegaly·
Venous or arterial thrombosis, including recurrent thrombosisProcedure Skills
·
Therapeutic phlebotomy·
Bone marrow aspiration and core biopsy (optional)Primary Interpretation of Tests
·
Peripheral smear·
Bone marrow aspiration and core biopsy (optional)Ordering and Understanding Tests
·
Bone marrow aspirate, biopsy, and special stains·
Chromosome analysis-peripheral blood and bone marrow·
Clotting assay, including factor levels and mixing studies·
Hemoglobin electrophoresis·
Iron studies·
Lymph node biopsy and lymphoid cell immunophenotype·
Radiologic, sonographic, and nuclear studies to assess adenopathy, splenomegaly, andred cell mass
·
Serum and urine electrophoresis·
Vitamin B12 levels and Schilling rest