Hematology

Overview

The discipline of hematology relates to the care of patients with disorders of the blood, bone

marrow, and lymphatic systems, including anemias, hematologic malignancies, and other clonal

processes, and congenital and acquired disorders of hemostasis, coagulation, and thrombosis.

The general internist should be competent in 1) the detection of abnormal physical, laboratory,

and radiologic findings relating to the lymphohematopoietic system; 2) the assessment of the

need for bone marrow aspirate and biopsy and lymph node biopsy; 3) the initial diagnostic

evaluation and management of the hemostatic and clotting system; 4) the assessment of the

indications and procedure for transfusion of blood and its separate components; 5) the

management of therapeutic and prophylactic anticoagulation; 6) the diagnosis and management

of common anemias; 7) the pharmacology and use of common chemotherapies; and 8) the

management of neutropenia/immunosuppression.

The range of competencies expected for a general internist will vary depending on the

availability of a hematologist in the primary care setting. For example, in some communities a

general internist may be responsible for bone marrow examination and administration of

chemotherapy for certain disorders in conjunction with consultative assistance from appropriate

hematologist and pathologist colleagues.

(N.B. Leukemias and lymphomas are found in the Oncology section.)

Common Clinical Presentations

· Abnormalities of peripheral smear

· Bleeding, bruising, or petechiae

· Family history of anemia or bleeding disorder

· Lymphadenopathy

· Pallor or fatigue

· Recurrent infections or fever/neutropenia

· Splenomegaly

· Venous or arterial thrombosis, including recurrent thrombosis

Procedure Skills

· Therapeutic phlebotomy

· Bone marrow aspiration and core biopsy (optional)

Primary Interpretation of Tests

· Peripheral smear

· Bone marrow aspiration and core biopsy (optional)

Ordering and Understanding Tests

· Bone marrow aspirate, biopsy, and special stains

· Chromosome analysis-peripheral blood and bone marrow

· Clotting assay, including factor levels and mixing studies

· Hemoglobin electrophoresis

· Iron studies

· Lymph node biopsy and lymphoid cell immunophenotype

· Radiologic, sonographic, and nuclear studies to assess adenopathy, splenomegaly, and

red cell mass

· Serum and urine electrophoresis

· Vitamin B12 levels and Schilling rest