Weekly Recommended Read Archive


May 4th, 2009 –    Weighing the Benefits and Burdens of Mammography Screening Among Women Age 80 Years or Older J Clin Oncol 27:1774-1780


May 11th, 2009 Epistemology and Uncertainty in Primary Care:  An Exploratory Study Fam Med 2009;41(5):319-26 Epistemology and variable physician reaction to uncertainty, see also What’s Your Epistemology? Think About It   Fam Med 2009;41(5):356-7)


May 26th, 2009 2 secondary analysis of 2 separate industry supported ARB trials which observed no difference in renal protection between ARB and placebo for low risk diabetics and pts with cardiovascular risks Effect of Candesartan on Microalbuminuria and Albumin Excretion Rate in Diabetes Annals of Int Med 2009; 151(1) Early Web Release May 19th, 2009 

See also Effect of Telmisartan on Renal Outcomes Annals of Int Med 2009;151(1), Early Web Release



June 3rd, 2009  Serum Cross-Reactive Antibody Response to a Novel Influenza A (H1N1) Virus After Vaccination with Seasonal Influenza Vaccine MMWR May 22, 2009 / 58(19);521-524


July 1st, 2009 Using the FIT Trial data, early (<3yr) monitoring of bone dexa after starting a potent bisphosphonate is found to be unjustified Value of routine monitoring of bone mineral density after starting bisphosphonate treatment: secondary analysis of trial data BMJ 2009;338:b2266


July 1st, 2009 Stent Placement in Patients With Atherosclerotic Renal Artery Stenosis and Impaired Renal Function Annals of Internal Medicine 16 June 2009 | Volume 150 Issue 12 | Pages 840-848


Aug 3rd, 2009  

The Myth of Prevention By ABRAHAM VERGHESE June 19, 2009 in the WSJ


Aug. 31st, 2009  Another warfarin contender on the horizon - Dabigatran versus Warfarin in Patients with Atrial Fibrillation N Engl J Med 2009;361



Sep 11th, 2009   Optimized Antidepressant Therapy and Pain Self-management in Primary Care Patients With Depression and Musculoskeletal Pain JAMA. 2009;301(20):2099-2110


Sep 21st, 2009   using contemporary stroke rates, the net treatment benefit for warfarin is re-evaluated The Net Clinical Benefit of Warfarin Anticoagulation in Atrial Fibrillation Ann Intern Med. 2009;151:297-305


Sept 29th, 2009 Getting Past Denial — The High Cost of Health Care in the United States J. M. Sutherland, E. S. Fisher, and J. S. Skinner  n engl j med 361;13


Week of October 7th, 2009 Prevalence of and screening for serious spinal pathology in patients presenting to primary care settings with acute low back pain ARTHRITIS & RHEUMATISM 2009, 60(10) 3072–3080


Podcast of the Week of October 19th, 2009 enlightenment from outside the medical literature, with review of the Dartmouth Atlas:  More is Less-from This American Life 10/9/2009


Ambulatory Podcast of the Week of October 26th, 2009 the 2nd part of health care reform enlightenment from outside the literature, this week the second part  Someone Else's Money  also refer to Part I  More is Less- Both from This American Life Oct 2009


Ambulatory Read of the Week of November 2nd, 2009  Rethinking Screening for Breast Cancer and Prostate Cancer JAMA. 2009;302(15):1685-1692


Ambulatory Read of the Week Week of November 9th, 2009 A Trial of Darbepoetin Alfa in Type 2 Diabetes

and Chronic Kidney Disease N Engl J Med 2009;361.


November 16th, 2009  10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study The Lancet, 374, Pages 1677 – 1686


November 17th, 2009   Screening for Breast Cancer: An Update for the U.S. Preventive Services Task Force Ann Intern Med November 17, 2009 vol. 151 no. 10 727-737 and New USPSTF Recommendation Statement


November 23rd, 2009    Cancer Incidence and Mortality After Treatment With Folic Acid and Vitamin B12 JAMA. 2009;302(19):2119-2126


December 7th, 2009 Prevalence of Clinically Relevant Incidental Findings on Chest Computed Tomographic Angiograms Ordered to Diagnose Pulmonary Embolism Arch Intern Med. 2009;169(21):1961-1965


December 21st, 2009 Revascularization versus Medical Therapy for Renal-Artery Stenosis N Engl J Med 2009;361:1953-62.



Podcast of the Week of December 21st, 2009 Annals of Internal Medicine Audio Summary 12/15/2009 updates on perioperative medicine and antiplatelets


January 5, 2009 Recommended Adult Immunization Schedule: United States, 2010 Ann Intern Med. 2010:152:36-9


January 11, 2010 Recommended Adult Immunization Schedule: United States, 2010 Ann Intern Med. 2010:152:36-9 The Annals Podcast of the week which gives more background on this recommendation is also highly recommended.


January 20, 2010  The Benefits and Harms of Mammography Screening Understanding the Trade-offs JAMA. 2010;303(2):164-165 Summary Table and associated Podcast


Week of January 27, 2010  from our own Dr. Barr Percent Emphysema, Airflow Obstruction, and Impaired Left Ventricular Filling N Engl J Med 2010;362:217-27  


February 2nd, 2010   Medicine's Ethical Responsibility for Health Care Reform — The Top Five List  H Brody n engl j med 2010;362:283-285


February 11th, 2010    NEJM article from our own Dr. Andrew Moran and colleagues Projected Effect of Dietary Salt Reductions on Future Cardiovascular Disease  published at www.nejm.org January 20, 2010


February 18th, 2010  interesting insights on the tobacco industry from Dr. Stanton Glantz who is commenting on Graham and Josanna’s recent article on cigar and pipe smoking in the Annals  Cigar and pipe smoking and lung function; interview with Stanton Glantz, PhD


March 9th, 2010 Assessment: Symptomatic treatment for muscle cramps (an evidence-based review) NEUROLOGY 2010;74:691-696


March 15th, 2010 I’m presuming this is not a shocker for you all Low Diagnostic Yield of Elective Coronary Angiography N Engl J Med 2010;362:886


March 22nd, interesting review and perspective on Screening young athletes for heart disease; interview with Barry Maron, MD from Annals (click on the March 2nd podcast)


  March 29th   Lenient versus Strict Rate Control in Patients with Atrial Fibrillation This article (10.1056/NEJMoa1001337) was published on March 15, 2010, at NEJM.org


April 5th, 2010 Cost Consciousness in Patient Care — What Is Medical Education’s Responsibility? Dr. Molly Cook - Posted by NEJM • March 31st, 2010


April 19th, 2010 since we dish out a lot of the newer and more costly phosphate binders, it’s a good time to review it’s indication and clinical evidence with this recent review article Oral Phosphate Binders in Patients with Kidney Failure N Engl J Med 2010;362:1312-24.


April 26th, 2010 concise overview of COPD mgmt Outpatient Management of Severe COPD Dennis E. Niewoehner, M.D. N Engl J Med 2010;362:1407-16.


 May 3rd learn about the health care reform bill The Patient Protection and Affordable Care Act of 2010; interview with Robert Doherty of the American College of Physicians April 6th, 2010


May 10th Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus and  Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus from the ACCORD study group N Engl J Med 2010;362


May 17th, 2010 do pts get “sicker” after moving to high intensity practice areas  Regional Variations in Diagnostic Practices published at www.nejm.org May 12, 2010


June 2nd, 2010  Annual High-Dose Oral Vitamin D and Falls and Fractures in Older Women  JAMA. 2010;303(18):1815-1822.


June 8, 2010  Caloric Sweetener Consumption and Dyslipidemia Among US Adults JAMA. 2010;303(15):1490-1497


June 15, 2010  Glucose-Independent, Black–White Differences in Hemoglobin A1c Levels - A Cross-sectional Analysis of 2 Studies Annals of Internal Medicine June 15, 2010, 152 (12)


June 21, 2010  Glucose-Independent, Black–White Differences in Hemoglobin A1c Levels - A Cross-sectional Analysis of 2 Studies Annals of Internal Medicine June 15, 2010, 152 (12) the article and associated editorial reviewed other many illness that cause alteration to HgbA1c results


June 28th billions of dollars in LFT testing and The Myth of Statin-Induced Hepatotoxicity Bader Am J Gastroenterol 2010;105:978–980   article suggested by Drs. Jones and Lebwohl, thnx


July 5th, 2010The Uncritical Use of High-Tech Medical Imaging N Engl J Med 2010; 363:4-6 great recommendation from Dr. Jones


July 13th updated joint position statement on  Aspirin for Primary Prevention of Cardiovascular Events in People With Diabetes  Diabetes Care June 2010 vol. 33 no. 6 1395-1402


July 23rd, 2010 Telemonitoring and self-management in the control of hypertension (TASMINH2): a randomised controlled trial Lancet  2010; 376:163-172 recommended by Dr. Janina Morrison also see editorial comment from our past faculty Dr.Gbenga Ogedegbe


July 30th, 2010 Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis BMJ 2010;341:c3691


August 10th, 2010 A Randomized Trial of Treatment for Acute Anterior Cruciate Ligament Tears N Engl J Med 2010; 363:331-342


August 16th, 2010 from our own Dr.  Neugut and Ben Lebwohl, a update and commentary on existing evidence Colonoscopy vs Sigmoidoscopy Screening Getting It Right JAMA. 2010;304(4):461-462


August 24thth, 2010 Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer N Engl J Med 2010; 363:733-742


September 6th, 2010 2 different conclusions from the same database on the risk of bisphosphonate and esophageal cancer Oral bisphosphonates and risk of cancer of oesophagus, stomach, and colorectum: case-control analysis within a UK primary care cohort BMJ 2010; 341:c4444 Exposure to Oral Bisphosphonates and Risk of Esophageal Cancer JAMA. 2010;304(6):657-663


September 13th, 2010 Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease N Engl J Med 2010; 363:918-929


September 21st, 2010  JAMA annual medical education theme issue has a few interesting studies this past week, check out these 2 educational intervention studies

An Educational Intervention for Contextualizing Patient Care and Medical Students' Abilities to Probe for Contextual Issues in Simulated Patients JAMA. 2010;304(11):1191-1197  and

Effect of Availability Bias and Reflective Reasoning on Diagnostic Accuracy Among Internal Medicine Residents JAMA. 2010;304(11):1198-1203


September 28th, 2010   Effect of Screening Mammography on Breast-Cancer Mortality in Norway N Engl J Med 2010; 363:1203-1210  and accompanied editorial from Dr. HG Welch Screening Mammography — A Long Run for a Short Slide? N Engl J Med 2010; 363:1276-1278


October 5th, 2010 cohort study finding elderly people with excessive fear of falling actually fell more Determinants of disparities between perceived and physiological risk of falling among elderly people: cohort study BMJ 2010; 341:c4165


October 12th, 2010 Idiopathic Urgency Urinary Incontinence  Ingrid Nygaard, M.D. N Engl J Med 2010; 363:1156-1162


October 18th, 2010 Tetanus and Pertussis Vaccination Coverage Among Adults Aged ≥18 Years --- United States, 1999 and 2008 MMWR October 15, 2010 / 59(40);1302-1306


October 25, 2010 51 page guidelines are generally painful to read, but this one is so relevant to our population. There is nothing super ground breaking here, but look through it and pick out relevant sections that is of interest to you. I found the reviews of the evidence on antiplatelet and anticoagulant primary and secondary prevention helpful given the new meds.  Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack Stroke. 2011;42:00-00


November 1st Managing Medications in Clinically Complex Elders  "There's Got to Be a Happy Medium"  Michael A. Steinman, MD; Joseph T. Hanlon, PharmD, MS  JAMA. 2010;304(14):1592-1601. doi:10.1001/jama.2010.1482


Week of November 8th, 2010 a very interesting article suggested by Dr. Andrew Moran Etiology and Diagnosis of Systolic Murmurs in Adults Steven McGee, MD The American Journal of Medicine (2010) 123, 913-921


November 16th, 2010  Evaluation and Management of Shoulder Pain in Primary Care Clinics  House, Jeff DO, FACP; Mooradian, Arshag MD Southern Medical Journal • Volume 103, Number 11, November 2010


Week of November 23rd Clinical Conversations Journal Watch Podcast 109: An overview of the American Heart Association meeting, with cardiologist Harlan Krumholz –updates from Dr. Krumholz  from the AHA meeting, and relevant discussions on the introduction of Dagabatran into clinical practice, and new data on refractory HTN management with kidney denervation


November 30th, 2010  Dietary Reference Intakes for Calcium and Vitamin D IOM Report Brief November 2010 link will bring you to a brief summary for the entire 999 page report see National Academies page


December 7th, 2010 spot-on observations on the current barriers with implementing HIT  Health information technology: fallacies and sober realities Karsh et al JAMIA 2010 17: 617-623


December 15th, 2010 A discussion on improving the informed consent process following an Annals study earlier this year which demonstrated a significant disconnect between the physicians’ and patients’ perception on the indications for PCIs. Clinical Conversations Journal Watch Podcast 100- Practical Informed Consent -Joe Elia with Guest Dr. Alicia Fernandez from UCSF


December 22nd  Invasive Dental Treatment and risk for vascular events: A self-controlled case series Minassian et al. Ann Intern Med 2010 Oct 19;153:499


December 29th, 2010 Oral Rivaroxaban for Symptomatic Venous Thromboembolism N Engl J Med 2010; 363:2499-2510


January 4th, 2011  What Is Value in Health Care? Michael E. Porter, Ph.D. N Engl J Med 2010; 363:2477-2481


January 11th from Annals of Internal Medicine December 21st, 2010 Dr. William Black and Dr. Peter Bach speaking on overuse of imaging test, as well as related challenges in doing comparative effectiveness imaging research


January 19th, 2011- again from the Annals of Internal Medicine-discussing primary care and subspecialty interactions with Dr. Hal Yee from UCSF from the Jan. 4th 2010 Podcast


January 27th, 2011 From the New Yorker The Hot Spotters

Can we lower medical costs by giving the neediest patients better care? Atul Gawande


Feb 10th, 2011 Axillary Dissection vs No Axillary Dissection in Women With Invasive Breast Cancer and Sentinel Node Metastasis Giuliano et al. JAMA. 2011;305(6):569-575


Feb 17th, 2011 The Implication of Therapeutic Complexity on Adherence to Cardiovascular Medication Choudhry et al.   Arch Intern Med. Published online January 10, 2011. doi:10.1001/archinternmed.2010.495


March 3rd 2011 Gout- A Clinical Practice Review from NEJM Tuhina Neogi, M.D., Ph.D. N Engl J Med 2011; 364:443-452


March 9th 2011 with all the ESRD pts in AIM, here is a review article from Nov 2010 on Hemodialysis by Dr. Himmelfarb and Ikizler  NEJM 2010;363:1833-45 followed by a recent article on new changes on HD reimbursement  Bundled Payment for ESRD — Including ESAs in Medicare's Dialysis Package by J Iglehart  NEJM 2011 364;593-5 and for more historical context Special Treatment — The Story of Medicare's ESRD Entitlement R Rettig NEJM 3011;364:596


March 16th  Streptococcal Pharyngitis Michael R. Wessels, M.D. N Engl J Med 2011; 364:648-655


March 22nd a meta-analysis from the JAMA on Serum Levels of Phosphorus, Parathyroid Hormone, and Calcium and Risks of Death and Cardiovascular Disease in Individuals With Chronic Kidney Disease JAMA. 2011;305(11):1119-1127 and associated Editorial


March 29, 2011  2011 ACCF/AHA Focused Update of the Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline) J Am Coll Cardiol, doi:10.1016/j.jacc.2011.02.009  with review of literature on newer anti-platelet agents and initial conservative vs. invasive strategy

March 29, 2011 ACE +ARB use in elderly results in a small but measurable mortality and renal dysfunction  The safety of combining angiotensin-converting-enzyme inhibitors with angiotensin-receptor blockers in elderly patients: a population-based longitudinal analysis CMAJ 10.1503/cmaj.101333


April 5th, 2011 Remember the heparin poisoning a year or two ago, it’s probably worthwhile learning about The Fight Against Counterfeit Drugs from the 60 minutes


April 14th, 2011  From the ACP Annals of Internal Medicine “Update on Anticoagulation” with Dr. Mark Crowther of McMaster


April 21st, 2010 Latent Tuberculosis Infection in the United States Horsburgh and 0Rubin, N Engl J Med 2011; 364:1441-1448  


May 2nd, 2011  Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis M Bolland et al BMJ 2011; 342:d2040, also associated Podcast from Journal Watch with Dr. Ian Reid  his work suggest that in treating 1000 pts x 5 yrs with Ca supplements, 3 fractures will be prevented, but 6 vascular events will be caused. The podcast also review some possible mechanisms of vascular harm and other existing literature.


May 12th, 2011  Duration of Treatment With Nonsteroidal Anti-Inflammatory Drugs and Impact on Risk of Death and Recurrent Myocardial Infarction in Patients With Prior Myocardial Infarction  Olsen et al Published online before print May 9, 2011 Circulation 2011;123:2226-35


May 18th, 2011 CDC press release for PREVENT-TB Trial just presented at the ATS showing the efficacy of a simpler, shorter 2 drug regimen for latent TB  here is the original small trial on the use of the regimen from 2006  Weekly Rifapentine/Isoniazid or Daily Rifampin/Pyrazinamide for Latent Tuberculosis in Household Contacts American Journal of Respiratory and Critical Care Medicine Vol 173. pp. 922-926


May 26, 2011a met-analysis trying to address the question of which third oral agent should be used in type 2 diabetes  Effect of Antihyperglycemic Agents Added to Metformin and a Sulfonylurea on Glycemic Control and Weight Gain in Type 2 Diabetes: A Network Meta-analysis Gross et al. Ann Intern Med. 2011;154:672-679.


June 2nd, 2011  The $640 Billion Question — Why Does Cost-Effective Care Diffuse So Slowly? Fuchs and Milstein NEJM 364: 21


June 21st, 2011 this study highlights the limitation of BP obtained in clinic and cautions decision making on single in office measurement. Measuring Blood Pressure for Decision Making and Quality Reporting: Where and How Many Measures? Powers et al. Ann Intern Med. 2011;154:781-788  Given the importance of BP measurements in clinical decision making, this Editorial calls for a more performance evaluation and regulation.


June 30th, 2011 Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening The National Lung Screening Trial Research Team June 29, 2011


July 8th, 2011 Case 20-2011 — A 30-Year-Old Man with Diarrhea after a Trip to the Dominican Republic N Engl J Med 2011; 364:2536